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CD47 forms a signaling complex with 5 Mar 2021 CD47 (CD47 Molecule) is a Protein Coding gene. Diseases associated with CD47 include Hereditary Spherocytosis and Neonatal Meningitis. 18 Apr 2020 Decades ago, one anti-CD47 antibody was injected into ovarian cancer patients in order to image the tumors; the study demonstrated some Monoclonal Antibody for studying CD47 in the Innate Immunity research area. 4 Feb 2020 18Background: Magrolimab (M, Hu5F9-G4) is an antibody targeting CD47, a “ don't eat me” signal for macrophages that enhances ovarian 27 Feb 2019 PURPOSETo evaluate the safety, pharmacokinetics, and pharmacodynamics of Hu5F9-G4 (5F9), a humanized IgG4 antibody that targets Kathleen Sakamoto and Irv Weissman has received a $1.37 million grant from CureSearch titled “Development of CD47 Monoclonal Antibody Therapy for HPA044659 Sigma-Aldrich. Anti-CD47 antibody produced in rabbit. Antibody Enhanced Validation.

Cd47 antibody

About Magrolimab Magrolimab is a first-in-class investigational monoclonal antibody against CD47 and macrophage checkpoint inhibitor that is designed to interfere with recognition of CD47 by the SIRPα receptor on macrophages, thus blocking the "don't eat me" signal used by cancer cells to avoid being ingested by macrophages. CD47 also known as Rh-associated protein, gp42, integrin-associated protein (IAP), and neurophilin, is a 42-52 kD member of the immunoglobulin superfamily containing a five-pass transmembrane attachment. CD47 is a receptor for thrombospondin-1 (TSP-1), a secreted glycoprotein that plays a role in vascular development and angiogenesis. CD47 Is has been found to be overexpressed in many different tumor cells.

18 Apr 2020 Decades ago, one anti-CD47 antibody was injected into ovarian cancer patients in order to image the tumors; the study demonstrated some Monoclonal Antibody for studying CD47 in the Innate Immunity research area. 4 Feb 2020 18Background: Magrolimab (M, Hu5F9-G4) is an antibody targeting CD47, a “ don't eat me” signal for macrophages that enhances ovarian 27 Feb 2019 PURPOSETo evaluate the safety, pharmacokinetics, and pharmacodynamics of Hu5F9-G4 (5F9), a humanized IgG4 antibody that targets Kathleen Sakamoto and Irv Weissman has received a $1.37 million grant from CureSearch titled “Development of CD47 Monoclonal Antibody Therapy for HPA044659 Sigma-Aldrich. Anti-CD47 antibody produced in rabbit.

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18 Apr 2020 Decades ago, one anti-CD47 antibody was injected into ovarian cancer patients in order to image the tumors; the study demonstrated some Monoclonal Antibody for studying CD47 in the Innate Immunity research area. 4 Feb 2020 18Background: Magrolimab (M, Hu5F9-G4) is an antibody targeting CD47, a “ don't eat me” signal for macrophages that enhances ovarian 27 Feb 2019 PURPOSETo evaluate the safety, pharmacokinetics, and pharmacodynamics of Hu5F9-G4 (5F9), a humanized IgG4 antibody that targets Kathleen Sakamoto and Irv Weissman has received a $1.37 million grant from CureSearch titled “Development of CD47 Monoclonal Antibody Therapy for HPA044659 Sigma-Aldrich. Anti-CD47 antibody produced in rabbit.

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Diseases associated with CD47 include Hereditary Spherocytosis and Neonatal Meningitis. Among its related pathways are Integrin Pathway and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include thrombospondin receptor activity. 2015-09-21 · Antibody generation. A cDNA fragment of human CD47 encoding the extracellular domain was cloned from a full-length human CD47 cDNA (Open Biosystems) and was fused to mouse Fc to generate a CD47/mFc fusion protein, which was used to immunize mice to produce monoclonal mouse anti-human CD47 antibodies. Anti-CD47 antibody produced in rabbit Prestige Antibodies ® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution Synonym: Anti-IAP, Anti-MER6, Anti-OA3 Human Protein Atlas Number HPA044659 Human Protein Atlas - View RNA & protein expression data of this target Anti-CD47 antibody–mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response Diane Tsenga,b,1, Jens-Peter Volkmer a,b, Stephen B. Willingham , Humberto Contreras-Trujilloa,b, 2021-04-22 · Clinical trials are research studies that involve people. The clinical trials on this list are studying Anti-CD47 Monoclonal Antibody Hu5F9-G4.

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Crystallization and structure determination. CD47-ECD/TJ-C4 complex was co- Antigen identified by monoclonal antibody 1D8 antibody; Antigenic surface determinant protein OA3 antibody; CD 47 antibody; CD47 antibody; CD47 antigen (Rh-related antigen, integrin-associated signal transducer) antibody; CD47 antigen antibody; CD47 glycoprotein antibody; CD47 molecule antibody; CD47_HUMAN antibody; IAP antibody; Integrin Associated Protein antibody Rabbit polyclonal CD47 antibody. Validated in WB, IHC, ICC/IF and tested in Mouse, Rat, Human.

Antibodies were deemed to occupy the same or overlapping epitope bin if the biotinylation signal was reduced. Crystallization and structure determination. CD47-ECD/TJ-C4 complex was co- Antigen identified by monoclonal antibody 1D8 antibody; Antigenic surface determinant protein OA3 antibody; CD 47 antibody; CD47 antibody; CD47 antigen (Rh-related antigen, integrin-associated signal transducer) antibody; CD47 antigen antibody; CD47 glycoprotein antibody; CD47 molecule antibody; CD47_HUMAN antibody; IAP antibody; Integrin Associated Protein antibody Rabbit polyclonal CD47 antibody. Validated in WB, IHC, ICC/IF and tested in Mouse, Rat, Human.
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Upon administration, anti-CD47 monoclonal antibody SHR-1603 preferentially binds to CD47 on tumor cells. CD47 antibody Rabbit Polyclonal from Proteintech validated in Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF),Enzyme-linked Immunosorbent Assay (ELISA) applications. This antibody reacts with human samples.

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The MIAP301 monoclonal antibody reacts with mouse CD47 otherwise known as integrin-associated protein (IAP). CD47 is an approximately 50 kDa glycosylated five transmembrane protein that is ubiquitously expressed by both hematopoietic cells such as T and B lymphocytes, monocytes, platelets and erythrocytes and non-hematopoietic cells. Magrolimab is a first-in-class investigational monoclonal antibody against CD47 and macrophage checkpoint inhibitor that is designed to interfere with recognition of CD47 by the SIRPα receptor on macrophages, thus blocking the "don't eat me" signal used by cancer cells to avoid being ingested by macrophages. Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu72 of human CD47 protein. Background CD47 is a five-pass transmembrane protein expressed on all normal cells.

Anti-CD47 antibody produced in rabbit. Antibody Enhanced Validation. Prestige Antibodies® Powered by Atlas Antibodies, affinity Description: Rabbit Polyclonal to CD47 Applications: ELISA, IHC, IP, WB Reactivity: Human, Mouse, Affinity Purified Leukocyte surface antigen CD47 Antibody.